diosgenin attenuates cardiac oxidative stress in streptozotocin- induced diabetic rat

background and objective: chronic diabetes mellitus (dm) leads to cardiovascular dysfunction. diosgenin is a natural steroidal saponin with cardiovascular protective potential. in this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats (n = 28) were divided into equal-sized control, diosgenin-treated control, diabetic, and diosgenin-treated diabetic groups. diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg). diosgenin was administered p.o. at a dose of 40 mg/kg for 7 weeks. some markers of oxidative stress including malondialdehyde (mda), superoxide dismutase (sod), catalase, and reduced glutathione (gsh) were measured in cardiac tissue homogenate. results: it was found out that diabetic group had an elevated mda content (p